Lou Diamond Phillips amerikalik kino, televizor va sahna aktyori, shuningdek, rejissyor va yozuvchi. Uning muvaffaqiyatli roli "La Bamba" filmida Ritchie Valens sifatida o'ynaganida boshlandi. U boshqa mashhur filmlarda Jose Chavez y Chavez sifatida "Young Guns I" va "II", Angel Guzman sifatida "Stand and Deliver" filmida, bu roli uchun qo'shimcha aktyor sifatida Oltin Globus mukofotiga nomzod bo'lgan, Hank Storm sifatida "Renegades", Jesse Rainfeather Goldman sifatida "Sioux City" filmida, u shuningdek rejissyor bo'lgan, Staff Sergeant John Monfriez sifatida "Courage Under Fire", Roy Knox sifatida "Brokedown Palace" va Wanda sifatida "Hollywood Homicide" filmida o'ynagan. U ko'plab televizion filmlarda ham rol o'ynagan. Uning eng mashhur televizion rollari "Prodigal Son"da Lt. Gil Arroyo, "Longmire"da Henry Standing Bear, "Stargate Universe"da Polkovnik David Telford, "Numb3rs"da Agent Ian Edgerton va "Wolf Lake"da John Kanin sifatida. U "Firebuds"da Chief Bill Bayani, "Elena of Valor"da Victor Delgado va "The Lion Guard"da Surak sifatida animatsion seriyalarda ovoz bergan. U "Trese", "Blindspot", "Blue Bloods", "Goliath", "NCIS: New Orleans", "Brooklyn Nine-Nine", "The Ranch", "Southland", "George Lopez" va "24" kabi televizion shoularda takroriy rollarga ega bo'lgan. U "Cougar Town" va "You're the Worst"da o'zini o'ynagan. Shuningdek, u "Bull", "The Cleaning Lady", "Search Party", "Criminal Minds", "Graves", "Training Day", "Ironside", "Chuck", "Psych", "Law & Order: SVU", "The Handler", "The Twilight Zone (2002)", "Spin City", "The Outer Limits", "Tales from the Crypt", "Miami Vice" va "Dallas (1985)" kabi ko'plab shoularda mehmon sifatida qatnashgan. U "The King and I" filmidagi roli uchun Tony mukofotiga nomzod bo'lgan. Aktyorlikdan tashqari, u 2009-yilgi Poker Jahon Chempionatlarida "No Limit Texas hold 'em" asosiy tadbirida 186-o'rinni egallab, mashhur bo'lib qolgan.
